A substantial fraction of the genome is transcribed in a cell type-specific manner, producing long non-coding RNAs (lncRNA) rather than protein-coding RNAs. We systematically characterized the transcriptome dynamics (both mRNA and lncRNA) during normal hematopoietic differentiation and hematological malignancies. We found lncRNAs to be regulated during differentiation and misregulated in disease. This page is a resource for easy exploration of lncRNA expression data and access to their genomic locations.
Links to the raw data and the published work can be found in the Downloads tab.
For more information, please visit our publication: Delás MJ, Sabin LR, Dolzhenko E et al (2017) lncRNA requirements for mouse acute myeloid leukemia and normal differentiation. eLife 6: e25607
Select lncRNAs from the diagram below or search the table. Selected lncRNAs will appear in the Plot and Heatmap tabs.
The coordinates will open a genome browser session with the lncRNA catalog and RNAseq coverage from this publication and the ATACseq data from Lara-Astiaso, Weiner et al. (2014)
The raw expression data can be downloaded from GEO: accession GSE90067
The SuperSeries linked to this publication also includes the high throughput sequencing readout from an in vivo shRNA screen that identified functional lncRNAs in AML and transcriptome analysis upon lncRNA knockdown: GEO GSE90072
For more information, please visit our publication: Delás MJ, Sabin LR, Dolzhenko E et al (2017) lncRNA requirements for mouse acute myeloid leukemia and normal differentiation. eLife 6: e25607.